Wisp Science AI Agent

by xuzhougeng• 1.1k•• Scanned•Claim this listing•Request removal

Research & Analysisai agentai for scienceai scientistai4sciencebioinformatics

Open-source, local-first desktop AI research workbench for scientific computing with Python/R, MCP bioinformatics tools, SSH/WSL/GPU runtimes, and OpenAI/Anthropic models.

Wisp Science is an open-source ai agent by xuzhougeng, written mainly in Rust, with 1,061 GitHub stars and the AGPL-3.0 license. Its code was last updated Nov 1, 2026.

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Wisp Science

The open-source, local-first AI research workbench.

WISP — Workspace for Intelligent Scientific Practice

English · 简体中文 · Website · Releases

Search the literature, run Python and R, query ~80 scientific databases, and keep the trail — figures, runs, decisions, and drafts — in one project. Your data, conversations, and credentials stay on your machines.

Bring your own model. Keep your science.

What you can do

An agent that does the work

Bring OpenAI-compatible or Anthropic models, or drive Codex / Claude Code over ACP. The agent reads and writes project files, runs shell, and loads reusable Skills (SKILL.md) without flooding the prompt. Approval gates stay on unless you opt into Full Permission.

Compute from laptop to remote servers

Persistent Python and R kernels keep variables across cells and turns; each conversation gets its own isolated kernel, so parallel sessions never share state. Register local, WSL, and SSH hosts once; probe hardware; submit long Runs with live logs. Keys live in the OS keyring, never in SQLite.

Built for science

PubMed, GEO, and ~80 other databases through bundled MCP servers. Offline previews for notebooks, PDFs, Office files, and images. Isolated explorations to try a direction without touching the mainline. A Publication Workspace that freezes manuscript revisions into verifiable Evidence Capsules.

A workbench that remembers

Restart and the full history is back. Undo a turn's file edits. Attach artifacts, files, and runtimes with @; search saved sessions with #; apply a skill with /. Encrypted manual sync and project transfer — nothing syncs in the background.

Get started

Open the download page, choose your operating system and processor, and download via Cloudflare. GitHub Releases is also available.
Open a bundled demo — no API key needed — to see a full RNA-seq trajectory.
Add a model in Settings → Models and start a project.

Platform	Package
Windows	Signed MSI / NSIS
macOS	Signed, notarized `.dmg` (Apple Silicon + Intel)
Linux	`.deb` / AppImage (x86_64 + aarch64)

Setup walkthrough: Quick Start · basic configuration · model profiles · ACP agents

Build from source, CLI, and architecture: development.

Documentation


Start	Basic setup · Models · Magpie · ACP agents
Research	Explorations · Evidence capsules · Case studies
Projects	Transfer · Sync · Global library
Compute	Terminals · Remote files · Transfers
Extend	Skills · Plugins · Delegation · Channels · Browser
Develop	Development · Headless eval

Community

Thanks to everyone who filed issues, sent PRs, and used Wisp on real projects. Special thanks to SpicyChicken6 for the molecular wordmark and three-wisp desktop icon designs.

Windows installers are Authenticode-signed with an SSL.com Personal ID (IV) code signing certificate through eSigner. SmartScreen reputation builds from download volume. Third-party notices live in development.

License

AGPL-3.0-only, except where a directory notes otherwise. Earlier releases keep the license published with them.

Citation

@software{xu2026wisp,
  author    = {Xu, Zhou-Geng},
  title     = {Wisp Science: a local-first AI research workbench},
  version   = {v1.5.0},
  year      = {2026},
  publisher = {Zenodo},
  doi       = {10.5281/zenodo.22009273},
  url       = {https://doi.org/10.5281/zenodo.22009273}
}

Desktop development is moving to one cross-platform GPUI frontend. The separate SwiftUI and WinUI desktop clients are retired; iOS/Android remain. Published desktop installers still use WebView during the migration.

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